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	<title>Comments for ceptional</title>
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	<link>http://alexholcombe.wordpress.com</link>
	<description>meta-science, open access, perception, statistics, neuroscience, ...</description>
	<lastBuildDate>Thu, 05 Nov 2009 06:22:28 +0000</lastBuildDate>
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		<title>Comment on Isfahan, Iran by veritas</title>
		<link>http://alexholcombe.wordpress.com/2009/05/28/isfahan-iran/#comment-64</link>
		<dc:creator>veritas</dc:creator>
		<pubDate>Thu, 05 Nov 2009 06:22:28 +0000</pubDate>
		<guid isPermaLink="false">http://alexholcombe.wordpress.com/?p=117#comment-64</guid>
		<description>it&#039;s beautiful.</description>
		<content:encoded><![CDATA[<p>it&#8217;s beautiful.</p>
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		<title>Comment on optimizing your coffee consumption by JH</title>
		<link>http://alexholcombe.wordpress.com/2009/09/27/optimizing-your-coffee-consumption/#comment-57</link>
		<dc:creator>JH</dc:creator>
		<pubDate>Wed, 14 Oct 2009 00:26:36 +0000</pubDate>
		<guid isPermaLink="false">http://alexholcombe.wordpress.com/?p=162#comment-57</guid>
		<description>Hey AH, there&#039;s a ton of stuff from the early 90s on caffeine tolerance and withdrawal. It&#039;s not better investigated (IMO) for a fairly simple reason - it isn&#039;t likely to kill you, or even hurt you, and neither is overdose / &#039;caffeinism&#039;. It, like alcohol, is harmless and complicated compared to meth &amp; heroin which are (proportionally) dangerous and simple.

A few things we can throw into the mix:

1) twin studies show initial sensitivity to caffeine has a fat genetic component. Borne out by observation: I have watched a single can of Coke give people the shakes.
2) expectation effects aren&#039;t particularly tops (there is a crap study by Kirsch from about 1993 on it) but conditioning is pretty possible - a very distinctive substance (i.e. smell/taste ) usually makes a good CS. This is the obvious explanation for why decaf works.
3) withdrawal symptoms are real, but as the general and receptor pharm. is so complicated, I don&#039;t think anyone&#039;s got much of an idea how they work yet. Review paper you want is Juliano and Griffiths, 2004 (I think in psychopharm.)
4) withdrawal will start from fairly low doses - http://jpet.aspetjournals.org/cgi/content/abstract/289/1/285

&quot;try leading a healthy lifestyle, regular exercise, healthy eating, herbal laxatives, green tea, juice, lots of vegetables, do some yoga, regular sleep pattern etc.&quot;

Or you could try drinking whiskey, beef jerky, working all night, being awesome, lifting jagged concrete boulders and not being a big tepid schoolgirl that thinks iced water and rice cakes is a treat.</description>
		<content:encoded><![CDATA[<p>Hey AH, there&#8217;s a ton of stuff from the early 90s on caffeine tolerance and withdrawal. It&#8217;s not better investigated (IMO) for a fairly simple reason &#8211; it isn&#8217;t likely to kill you, or even hurt you, and neither is overdose / &#8216;caffeinism&#8217;. It, like alcohol, is harmless and complicated compared to meth &amp; heroin which are (proportionally) dangerous and simple.</p>
<p>A few things we can throw into the mix:</p>
<p>1) twin studies show initial sensitivity to caffeine has a fat genetic component. Borne out by observation: I have watched a single can of Coke give people the shakes.<br />
2) expectation effects aren&#8217;t particularly tops (there is a crap study by Kirsch from about 1993 on it) but conditioning is pretty possible &#8211; a very distinctive substance (i.e. smell/taste ) usually makes a good CS. This is the obvious explanation for why decaf works.<br />
3) withdrawal symptoms are real, but as the general and receptor pharm. is so complicated, I don&#8217;t think anyone&#8217;s got much of an idea how they work yet. Review paper you want is Juliano and Griffiths, 2004 (I think in psychopharm.)<br />
4) withdrawal will start from fairly low doses &#8211; <a href="http://jpet.aspetjournals.org/cgi/content/abstract/289/1/285" rel="nofollow">http://jpet.aspetjournals.org/cgi/content/abstract/289/1/285</a></p>
<p>&#8220;try leading a healthy lifestyle, regular exercise, healthy eating, herbal laxatives, green tea, juice, lots of vegetables, do some yoga, regular sleep pattern etc.&#8221;</p>
<p>Or you could try drinking whiskey, beef jerky, working all night, being awesome, lifting jagged concrete boulders and not being a big tepid schoolgirl that thinks iced water and rice cakes is a treat.</p>
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		<title>Comment on optimizing your coffee consumption by alexholcombe</title>
		<link>http://alexholcombe.wordpress.com/2009/09/27/optimizing-your-coffee-consumption/#comment-55</link>
		<dc:creator>alexholcombe</dc:creator>
		<pubDate>Thu, 08 Oct 2009 02:08:38 +0000</pubDate>
		<guid isPermaLink="false">http://alexholcombe.wordpress.com/?p=162#comment-55</guid>
		<description>Hi April, at last an easy question- coffee usually has more caffeine than tea.</description>
		<content:encoded><![CDATA[<p>Hi April, at last an easy question- coffee usually has more caffeine than tea.</p>
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		<title>Comment on optimizing your coffee consumption by April Logan</title>
		<link>http://alexholcombe.wordpress.com/2009/09/27/optimizing-your-coffee-consumption/#comment-54</link>
		<dc:creator>April Logan</dc:creator>
		<pubDate>Thu, 08 Oct 2009 00:15:56 +0000</pubDate>
		<guid isPermaLink="false">http://alexholcombe.wordpress.com/?p=162#comment-54</guid>
		<description>I drink about one 8 oz cup of green tea Monday through Friday when I think that I might need it most, early in the morning or mid afternoon, and I drink coffee on the weekends.  However, I try to avoid any type of caffeine at night because it leads to restless sleep.  I’ll move to my question, now that I have obliterated your coffee buzz with the wandering tale of my addiction. If my memory serves me correctly, I believe that tea has more caffeine in it than coffee. Yet, for some reason, I tend to experience a stronger jolt to the system with coffee. I am wondering whether anyone is aware of a study that explains why my body’s response to coffee and tea does not seem commensurate with the amount of caffeine they contain.</description>
		<content:encoded><![CDATA[<p>I drink about one 8 oz cup of green tea Monday through Friday when I think that I might need it most, early in the morning or mid afternoon, and I drink coffee on the weekends.  However, I try to avoid any type of caffeine at night because it leads to restless sleep.  I’ll move to my question, now that I have obliterated your coffee buzz with the wandering tale of my addiction. If my memory serves me correctly, I believe that tea has more caffeine in it than coffee. Yet, for some reason, I tend to experience a stronger jolt to the system with coffee. I am wondering whether anyone is aware of a study that explains why my body’s response to coffee and tea does not seem commensurate with the amount of caffeine they contain.</p>
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		<title>Comment on optimizing your coffee consumption by Arvind</title>
		<link>http://alexholcombe.wordpress.com/2009/09/27/optimizing-your-coffee-consumption/#comment-50</link>
		<dc:creator>Arvind</dc:creator>
		<pubDate>Tue, 29 Sep 2009 20:06:12 +0000</pubDate>
		<guid isPermaLink="false">http://alexholcombe.wordpress.com/?p=162#comment-50</guid>
		<description>Veritas - how about you let other people decide for themselves what their goals in life are?</description>
		<content:encoded><![CDATA[<p>Veritas &#8211; how about you let other people decide for themselves what their goals in life are?</p>
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		<title>Comment on optimizing your coffee consumption by veritas</title>
		<link>http://alexholcombe.wordpress.com/2009/09/27/optimizing-your-coffee-consumption/#comment-49</link>
		<dc:creator>veritas</dc:creator>
		<pubDate>Tue, 29 Sep 2009 16:11:34 +0000</pubDate>
		<guid isPermaLink="false">http://alexholcombe.wordpress.com/?p=162#comment-49</guid>
		<description>we&#039;ve peandered drugs for centuries.. e.g. khat, chewing caffeine is considered a prized pastime in some countries. try leading a healthy lifestyle, regular exercise, healthy eating, herbal laxatives, green tea, juice, lots of vegetables, do some yoga, regular sleep pattern etc.

sounds like y&#039;all work-stress constipated. breathe, relax, walk in the park, take it easy. if withdrawal concerns are such an issue, mix black coffee (no milk-milk is used to flush caffeine from body, no sugar) dunk in a tea bag (can be abit potent mix) then transition to just tea.</description>
		<content:encoded><![CDATA[<p>we&#8217;ve peandered drugs for centuries.. e.g. khat, chewing caffeine is considered a prized pastime in some countries. try leading a healthy lifestyle, regular exercise, healthy eating, herbal laxatives, green tea, juice, lots of vegetables, do some yoga, regular sleep pattern etc.</p>
<p>sounds like y&#8217;all work-stress constipated. breathe, relax, walk in the park, take it easy. if withdrawal concerns are such an issue, mix black coffee (no milk-milk is used to flush caffeine from body, no sugar) dunk in a tea bag (can be abit potent mix) then transition to just tea.</p>
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		<title>Comment on optimizing your coffee consumption by alexholcombe</title>
		<link>http://alexholcombe.wordpress.com/2009/09/27/optimizing-your-coffee-consumption/#comment-48</link>
		<dc:creator>alexholcombe</dc:creator>
		<pubDate>Tue, 29 Sep 2009 10:54:34 +0000</pubDate>
		<guid isPermaLink="false">http://alexholcombe.wordpress.com/?p=162#comment-48</guid>
		<description>Jason: good ideas. Indeed, who could forget Siegel et al. 1982!—where a usually-tolerated dose of heroin administered in an unfamiliar context can result in fatal overdose, due to the conditioned tolerance associated with the context. Unfortunately your suggestion #3 won&#039;t work for me, because administration time is already tightly constrained by my daily cycle and sleep considerations. #2 or #1 might be ok but unfortunately there is another factor that pushes me towards using coffee: the good taste.
Steve: Thanks I&#039;ll have to check it out.
Arvind: That&#039;s good news, I hope cycling on and off will continue to work for me too.</description>
		<content:encoded><![CDATA[<p>Jason: good ideas. Indeed, who could forget Siegel et al. 1982!—where a usually-tolerated dose of heroin administered in an unfamiliar context can result in fatal overdose, due to the conditioned tolerance associated with the context. Unfortunately your suggestion #3 won&#8217;t work for me, because administration time is already tightly constrained by my daily cycle and sleep considerations. #2 or #1 might be ok but unfortunately there is another factor that pushes me towards using coffee: the good taste.<br />
Steve: Thanks I&#8217;ll have to check it out.<br />
Arvind: That&#8217;s good news, I hope cycling on and off will continue to work for me too.</p>
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		<title>Comment on optimizing your coffee consumption by Jason Tangen</title>
		<link>http://alexholcombe.wordpress.com/2009/09/27/optimizing-your-coffee-consumption/#comment-45</link>
		<dc:creator>Jason Tangen</dc:creator>
		<pubDate>Mon, 28 Sep 2009 22:06:19 +0000</pubDate>
		<guid isPermaLink="false">http://alexholcombe.wordpress.com/?p=162#comment-45</guid>
		<description>You might also check out Shep Siegel&#039;s work on situational specificity.
http://bit.ly/1GTJJA

Rather than increasing the dosage or going cold turkey, you could simply change the cues that are normally associated with the caffeine hit.

To boost it&#039;s effects, you could:

1. Change the form of the caffeine: Remington, Roberts, and Glautier (1997) demonstrated that the same amount of alcohol induced less impairment when college students consumed the alcohol in an alcohol-associated beverage (beer-flavored beverage) rather than a liquid that had not previously been associated with alcohol (a blue, peppermint-flavored beverage), (Siegel, 2008). The same should hold for caffeine. A cold, caffeinated drink (e.g., red bull or V) ought to enhance the effect compared to the usual hot cup of coffee that tends to accompany your hit.

2. Change the medium: Similarly, tolerance to the cardiac effect of caffeine is more pronounced if the caffeine is administered in the context of the usual caffeine-administration cues (i.e., consumed in coffee) than if the same blood level of caffeine is obtained with an administration procedure that does not incorporate these gustatory cues (i.e., intravenous administration; Siegel, Kim, &amp; Sokolowska, 2003). So take it intravenously or in pill form.

3. Change the time of consumption: Presumably, any disruption to your normal schedule will enhance the effect given Shep&#039;s conditioned compensatory response explanation. If you set the caffeine hit to random, you can&#039;t anticipate it, and thereby enhance the effect.

Cheers,
Jason</description>
		<content:encoded><![CDATA[<p>You might also check out Shep Siegel&#8217;s work on situational specificity.<br />
<a href="http://bit.ly/1GTJJA" rel="nofollow">http://bit.ly/1GTJJA</a></p>
<p>Rather than increasing the dosage or going cold turkey, you could simply change the cues that are normally associated with the caffeine hit.</p>
<p>To boost it&#8217;s effects, you could:</p>
<p>1. Change the form of the caffeine: Remington, Roberts, and Glautier (1997) demonstrated that the same amount of alcohol induced less impairment when college students consumed the alcohol in an alcohol-associated beverage (beer-flavored beverage) rather than a liquid that had not previously been associated with alcohol (a blue, peppermint-flavored beverage), (Siegel, 2008). The same should hold for caffeine. A cold, caffeinated drink (e.g., red bull or V) ought to enhance the effect compared to the usual hot cup of coffee that tends to accompany your hit.</p>
<p>2. Change the medium: Similarly, tolerance to the cardiac effect of caffeine is more pronounced if the caffeine is administered in the context of the usual caffeine-administration cues (i.e., consumed in coffee) than if the same blood level of caffeine is obtained with an administration procedure that does not incorporate these gustatory cues (i.e., intravenous administration; Siegel, Kim, &amp; Sokolowska, 2003). So take it intravenously or in pill form.</p>
<p>3. Change the time of consumption: Presumably, any disruption to your normal schedule will enhance the effect given Shep&#8217;s conditioned compensatory response explanation. If you set the caffeine hit to random, you can&#8217;t anticipate it, and thereby enhance the effect.</p>
<p>Cheers,<br />
Jason</p>
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		<title>Comment on optimizing your coffee consumption by Steve Silberman</title>
		<link>http://alexholcombe.wordpress.com/2009/09/27/optimizing-your-coffee-consumption/#comment-44</link>
		<dc:creator>Steve Silberman</dc:creator>
		<pubDate>Mon, 28 Sep 2009 16:49:29 +0000</pubDate>
		<guid isPermaLink="false">http://alexholcombe.wordpress.com/?p=162#comment-44</guid>
		<description>Alex, FYI, Dale Pendell&#039;s &#039;Pharmako/Dynamis&#039; (vol. 2 of a brilliant trilogy on drugs) has great insight/history on caffeine.

http://bit.ly/L2Yfl</description>
		<content:encoded><![CDATA[<p>Alex, FYI, Dale Pendell&#8217;s &#8216;Pharmako/Dynamis&#8217; (vol. 2 of a brilliant trilogy on drugs) has great insight/history on caffeine.</p>
<p><a href="http://bit.ly/L2Yfl" rel="nofollow">http://bit.ly/L2Yfl</a></p>
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		<title>Comment on optimizing your coffee consumption by Arvind Narayanan</title>
		<link>http://alexholcombe.wordpress.com/2009/09/27/optimizing-your-coffee-consumption/#comment-43</link>
		<dc:creator>Arvind Narayanan</dc:creator>
		<pubDate>Mon, 28 Sep 2009 12:02:18 +0000</pubDate>
		<guid isPermaLink="false">http://alexholcombe.wordpress.com/?p=162#comment-43</guid>
		<description>I wish I&#039;d posted the links to all the papers I consulted when I wrote that essay. I don&#039;t have them any more.

One additional change I&#039;ve made since then is to switch to pills. This way I know exactly how much caffeine I&#039;m getting. I&#039;ve gotten the broad strategy I wrote about to work rather well, and consistently, and I&#039;m able to optimize at a finer level these days.</description>
		<content:encoded><![CDATA[<p>I wish I&#8217;d posted the links to all the papers I consulted when I wrote that essay. I don&#8217;t have them any more.</p>
<p>One additional change I&#8217;ve made since then is to switch to pills. This way I know exactly how much caffeine I&#8217;m getting. I&#8217;ve gotten the broad strategy I wrote about to work rather well, and consistently, and I&#8217;m able to optimize at a finer level these days.</p>
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